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Finished Medicine Tablet Amoxicillin And Clavulanic Acid Tablets 4 / 7 / 10 Tabs / Blister

Categories Medicine Tablet
Brand Name: UNP/AMOCLA
Model Number: 500MG+125MG
Certification: GMP
Place of Origin: China
MOQ: 5000boxes
Price: USD2.95-3.10/ box FOB SHANGHAI OR GUANGZHOU
Payment Terms: L/C, T/T, Western Union, D/P
Supply Ability: 1000000tablets /MONTH
Delivery Time: 30-35days after order is setted
Packaging Details: 10tablets/blister, 2blister/box, 100boxes/carton
Product name: Amoxicillin 500mg+Clavulanate acid 125mg
Appearace: white printed tablets
Composition: Each tablet contains: Amoxicillin 500mg + Clavulanate acid 125mg
Indications: treat certain infections caused by bacteria, including infections of the ears, lungs, sinus, skin, and urinary tract. Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria. Clavulanic acid
Assay: >98.0%
Specification: 500mg +125mg
Quality standard: USP/BP
Shelf time: 3 years
Package: 10tablets/blister, 2blisters/box, 1000boxes/carton
Storage: Store below 25 degrees celsius. Protect from moisture. Keep out of reach of children.
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    Finished Medicine Tablet Amoxicillin And Clavulanic Acid Tablets 4 / 7 / 10 Tabs / Blister

    GMPCertified Best Quality Amoxicillin 500mg+ Clavulanic acid 125mg tablet, 4tabs, 7tabs,10tabs/blister
    1 Name of the medicinal product

    Amoxicillin 500mg+ Clavulanate acid 125mg tablet

    2 Qalitative and quantitative composition

    Active Ingredients:

    Amoxicillin USP/BP
    Acid Clavulanate

    500 mg/tablet
    125mg/tablet


    3. Pharmaceutical form

    Tablet for oral administration.

    4. Product Descriptions:

    Co-amoxiclav is the British Approved Name for the combination antibiotic containing amoxicillin trihydrate, a β-lactam antibiotic, with potassium clavulanate, a β-lactamase inhibitor. This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce β-lactamase.

    5.Pharmacokinetics

    Clavulanic acid has a high affinity for and binds to certain β-lactamases that generally inactivate amoxicillin by hydrolyzing its β-lactam ring. Combining clavulanate potassium with amoxicillin extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.
    Distribution
    Protein binding: About 25% (Clavulanic acid); about 18% (Amoxicillin). Amoxicillin distributes readily into most body tissues and fluids except the brain and spinal fluid.
    Excretion
    Half-life after oral admin: 1.3 hours (Amoxicillin); 1 hour (Clavulanic acid). About 50-70% of amoxicillin and 25-40% of clavulanic acid are excreted unchanged in urine during the 1st 6 hours after admin.

    Amoxicillin + Clavulanic Acid Indications / Amoxicillin + Clavulanic Acid Uses

    Information Not Available

    Amoxicillin + Clavulanic Acid Adverse Reactions / Amoxicillin + Clavulanic Acid
    6.Side Effects

    Nausea, vomiting, diarrhoea, indigestion, rash and urticaria, candida superinfection.
    Potentially Fatal: Anaphylactic reaction with CV collapse esp with parenteral use.

    7.Precautions

    Prescribing amoxicillin and clavulanate potassium tablets in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. While amoxicillin and clavulanate potassium tablets possess the characteristic low toxicity of the penicillin group of antibiotics, periodic assessment of organ system functions, including renal, hepatic and hematopoietic function, is advisable during prolonged therapy.
    A high percentage of patients with mononucleosis who receive ampicillin develop an erythematous skin rash. Thus, ampicillin-class antibiotics should not be administered to patients with mononucleosis.
    The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur (usually involving Pseudomonas or Candida), the drug should be discontinued and/or appropriate therapy instituted.


    8.Special Precautions

    History of allergy especially to cephalosporins, infectious mononucleosis, severe renal impairment.


    9.Other Drug Interactions

    Allopurinol may reduce renal tubular secretion of amoxicillin thus increasing the serum levels of amoxicillin. Concurrent use may reduce the efficacy of oral contraceptives.


    10.Other Interactions

    Food Interaction
    None on absorption. But incidence and severity of GI effects may be reduced.

    11.Dosage

    Oral
    Upper and lower respiratory tract infections
    Adult: Based on amoxicillin dose, 250-500 mg every 8 hours or 500-750 mg every 12 hours.
    Child: Based on amoxicillin dose: 125-250 mg every 8 hours. Children weighing <40 kg: 20-40 mg/kg/day in divided doses every 8 hours. Infants <3 months: up to 30 mg/kg/day in divided doses every 12 hours.
    Oral
    Otitis media
    Adult: Based on amoxicillin dose, 250-500 mg every 8 hours or 500-750 mg every 12 hours.
    Child: Based on amoxicillin dose: 125-250 mg every 8 hours. Children weighing <40 kg: 20-40 mg/kg/day in divided doses every 8 hr. Infants <3 months: up to 30 mg/kg/day in divided doses every 12 hours.
    Oral
    Sinusitis
    Adult: Based on amoxicillin dose, 250-500 mg every 8 hours or 500-750 mg every 12 hours.
    Child: Based on amoxicillin dose: 125-250 mg every 8 hours. Children weighing <40 kg: 20-40 mg/kg/day in divided doses every 8 hr. Infants <3 months: up to 30 mg/kg/day in divided doses every 12 hours.
    Oral
    Skin and soft tissue infections
    Adult: Based on amoxicillin dose, 250-500 mg every 8 hours or 500-750 mg every 12 hours.
    Child: Based on amoxicillin dose: 125-250 mg every 8 hours. Children weighing <40 kg: 20-40 mg/kg/day in divided doses every 8 hours. Infants <3 months: up to 30 mg/kg/day in divided doses every 12 hours.
    Oral
    Susceptible infections
    Adult: Based on amoxicillin dose, 250-500 mg every 8 hours or 500-750 mg every 12 hours.
    Child: Based on amoxicillin dose: 125-250 mg every 8 hours. Children weighing <40 kg: 20-40 mg/kg/day in divided doses every 8 hours. Infants <3 months: up to 30 mg/kg/day in divided doses every 12 hours.
    Oral
    Dental abscesses
    Adult: Based on amoxicillin dose: 3 g as a single dose, followed by another dose 8 hours later.
    Oral
    Acute uncomplicated urinary tract infections
    Adult: Based on amoxicillin dose: 3 g as a single dose, followed by another dose 10-12 hours later.
    Oral
    Severe or recurrent respiratory tract infections
    Adult: Based on amoxicillin dose: 3 g bid.
    Oral
    Uncomplicated gonorrhoea
    Adult: Based on amoxicillin dose: 3 g as a single dose with 1 g of oral probenecid.
    Oral
    Prophylaxis of endocarditis
    Adult: Based on amoxicillin dose: 2 or 3 g as a single dose. To be taken 1 hour before the dental procedure.
    Oral
    H.pylori infection
    Adult: Based on amoxicillin dose: 0.75-1 g bid or 500 mg tid. To be taken with metronidazole or claithromycin and a PPI or ranitidine bismuth citrate.
    Parenteral
    Susceptible infections
    Adult: Based on amoxicillin dose: 500 mg every 8 hr. In severe infections, may increase to 1 g every 6 hours. Can be given via IM inj or slow IV injection over 3-4 minutes or IV infusion over 30-60 minutes.
    Child: <10 years: 50-100 mg/kg/day in divided doses.
    Reconstitution
    Powder for oral suspension: Reconstitute with appropriate amount of water as specified on the bottle. Shake vigorously until suspended.

    12. List of Contraindications
    Amoxicillin + Clavulanic Acid and Pregnancy

    Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

    Amoxicillin + Clavulanic Acid and Lactation

    Caution when used during lactation

    Ampicillin-class antibiotics are excreted in human milk; therefore, caution should be exercised when Amoxicillin and Clavulanate Potassium is administered to a nursing woman.

    Amoxicillin + Clavulanic Acid and Children

    Safety and efficacy of Amoxicillin and Clavulanate Potassium for Oral Suspension 600 mg/42.9 mg per 5 mL in infants younger than 3 months have not been established. Safety and efficacy of Amoxicillin and Clavulanate Potassium for Oral Suspension 600 mg/42.9 mg per 5 mL have been demonstrated for treatment of acute otitis media in infants and children 3 months to 12 years

    Amoxicillin + Clavulanic Acid and Other Contraindications

    Penicillin allergy

    13.Storage

    Oral
    Store below 25°C.
    Parenteral
    Store below 25°C.


    Product Tags:

    medical pills

      

    small round white pill

      
    Quality Finished Medicine Tablet Amoxicillin And Clavulanic Acid Tablets 4 / 7 / 10 Tabs / Blister for sale
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